US stock futures pointed to a sharply lower open on Tuesday, with the Dow Jones Industrial Average set to drop more than 400 points as crude oil prices climbed toward $100 a barrel, reigniting inflation concerns ahead of crucial inflation data later this week.

Dow futures slid 0.7%, while S&P 500 futures lost 0.2% and Nasdaq 100 futures slipped 0.1% in early trading. The moves came as Brent crude rose above $99 after attacks on Saudi energy infrastructure heightened fears of a broader Middle East supply disruption. West Texas Intermediate (WTI) also advanced, trading above $94.

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The surge in oil prices has revived worries that the conflict could disrupt Gulf supplies just as inflation remains above the Federal Reserve's target. Treasury yields edged higher, with the 10-year yield moving toward 4.81%, adding pressure on equities.

Inflation data takes center stage

Investors now face a critical stretch of economic data, with the August producer price index (PPI) due Thursday and the consumer price index (CPI) on Friday, both at 8:30 am ET. Economists expect headline CPI to remain around 3.4% year over year, while core inflation may ease to 2.4%.

A softer reading would support the case for the Fed to hold rates steady at its September 15-16 meeting. However, an upside surprise could push bond yields higher and deepen the selloff in equities. The market's focus has shifted from payrolls to inflation, as the recent jobs report showed resilience but did little to clarify the Fed's next move.

Fed rate hike odds remain elevated

Markets are currently pricing in roughly a 60% probability of a rate increase at the September meeting. Those odds climbed after August payrolls rose by 162,000, well above forecasts, and July employment was revised higher. The strong labor report reduced concerns about an imminent slowdown and gave policymakers more room to focus on inflation.

For investors, the key question is whether this week's price data confirm that the economy can absorb another increase in borrowing costs. A hot CPI reading could solidify expectations for a hike, while a cool print might ease pressure on equities.

Dow's drag from Amgen

The Dow's sharper decline is not solely due to oil. Amgen fell more than 5% in premarket trading after Novartis said its late-stage pelacarsen trial failed to meet its primary cardiovascular endpoint. Analysts noted that Amgen's high share price gives it an outsized influence on the price-weighted Dow.

Energy stocks moved in the opposite direction, with Marathon Petroleum and Occidental Petroleum gaining as crude prices climbed. This divergence highlights the mixed impact of rising oil prices on different sectors.

Chips rise, crypto-linked stocks retreat

Technology stocks showed relative resilience, with Intel gaining about 2.5%, AMD rising more than 1%, and Nvidia edging higher in premarket trading. Optimism around AI spending continues to support chipmakers, even as broader market sentiment sours.

Conversely, crypto-linked stocks moved lower as bitcoin slipped below $78,500. Coinbase and Strategy both fell before the bell. The split suggests investors are still willing to back selected growth themes, but Tuesday's broader direction will remain tied to oil, yields, and the inflation outlook.

As the trading day unfolds, market participants will closely monitor oil prices and any headlines from the Middle East, while positioning for the upcoming inflation reports that could shape the Fed's decision.

This article is for informational purposes only and does not constitute financial advice.